1. What is the MDRD GFR Equation?

The MDRD (Modification of Diet in Renal Disease) equation estimates glomerular filtration rate (GFR) from serum creatinine, age, sex, and race. It is widely used for assessing kidney function and staging chronic kidney disease.

2. How Does the Calculator Work?

The calculator uses the MDRD equation:

Where:

• \( SCr \) — Serum creatinine (mg/dL)
• \( Age \) — Age in years
• 0.742 — Female multiplier
• 1.212 — Black race multiplier

Explanation: The equation estimates kidney function based on serum creatinine levels adjusted for age, gender, and race factors.

3. Importance of GFR Calculation

Details: GFR estimation is essential for diagnosing kidney disease, monitoring disease progression, and determining appropriate treatment strategies and medication dosages.

4. Using the Calculator

Tips: Enter serum creatinine in mg/dL, age in years, select gender and race. All values must be valid (creatinine > 0, age between 1-120).

5. Frequently Asked Questions (FAQ)

Q1: What is the difference between MDRD and CKD-EPI equations?
A: MDRD is more accurate in patients with reduced kidney function, while CKD-EPI performs better at higher GFR levels and is less likely to misclassify individuals.

Q2: What are the limitations of the MDRD equation?
A: The equation may be less accurate in elderly patients, those with extreme body sizes, pregnant women, and populations with different muscle mass.

Q3: When should GFR be calculated using MDRD?
A: MDRD is commonly used for staging chronic kidney disease and monitoring kidney function in clinical practice.

Q4: How often should GFR be monitored?
A: Frequency depends on the patient's condition, but typically it's monitored regularly in patients with known kidney disease or risk factors.

Q5: Can MDRD be used for drug dosing?
A: While MDRD provides GFR estimates, some medications may require more precise GFR measurements for accurate dosing.